Product Overview

Overview

Tissue Inhibitor of Metalloproteinase 1 (TIMP1) is a regulatory protein that inhibits the activity of matrix metalloproteinases (MMPs), regulating the degradation and remodeling of the extracellular matrix (ECM). It binds to MMPs in a 1:1 ratio to suppress enzymatic activity, playing an important role in tissue regeneration and homeostasis maintenance. This recombinant TIMP1 is produced through an E. coli expression system, offering high purity and stable activity for application in a wide range of research and formulation contexts.

Application Area

Applications

Research Applications
  • MMP inhibition and ECM remodeling research
  • Tissue regeneration and wound healing studies
  • Extracellular matrix-related signal transduction studies
  • Protease activity regulation research
Cosmetic Applications
  • Skin structural improvement and ECM maintenance formulations
  • Collagen degradation-inhibiting anti-aging products
  • Skin elasticity and wrinkle improvement products
  • Skin protection and regeneration formulations
Properties

Properties

ItemDescription
Product nameTIMP1 (Tissue inhibitor of metalloproteinase 1, human)
Manufacturing SourceRecombinant, E. coli
Purity≥ 98 %, as determined by Coomassie stained SDS-PAGE.
Endotoxin≤ 0.4 EU/μg of protein
Protein ContentQuantified using validated methods
Biological activityIC50 ≤ 0.5 μg/mL (MMP-1 inhibition assay)
Predicted N terminalMet1
Molecular Weight20840.03 Da (185 amino acids).
FormulationSterile filtered through a 0.2 micron filtered 1X DPBS, pH 7.4.
Storage and StabilityStore at 2–8 °C for short-term use (1–2 weeks) and at -20 °C or below for long-term storage (> 2 weeks). Avoid repeated freeze–thaw cycles.
TIMP1 Activity Data